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咪唑斯汀 | 108612-45-9

咪唑斯汀结构式图片|108612-45-9结构式图片 六合彩开什么
中文名称: 咪唑斯汀
英文名称: 2-((1-(1-(4-Fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidin-4-yl)(methyl)amino)pyrimidin-4(1H)-one
CAS No.: 108612-45-9 | 分子式: C24H25N6OF | 分子量: 432.4933
如需查看该化合物的详细结构式,mol文件,smile, InChi 请点击:咪唑斯汀结构式
MSDS:咪唑斯汀msds
基本信息
中文别名:
咪唑斯汀 2-[[1-[1-[(4-氟苯基)甲基]苯并咪唑-2-基]-4-哌啶基]-甲基氨基]-3H-嘧啶-4-酮 咪唑司汀 咪唑司汀(标准品) 咪唑斯汀 咪唑司汀; Mizolastine 2-((1-(1-(4-Fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-piperidin-4-yl)(methyl)amino)pyrimidin-4(1H)-one 2-((1-(1-(4-Fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidin-4-yl)(methyl)amino)pyrimidin-4(1H)-one 3-甲基-2-(三正丁基锡)吡啶 7-氟-2H-1,4-苯并恶嗪-3(4H)-酮 Mizolastine 咪唑司汀 氟甲喹钠 加拿大TRCCAS:108612-45-9,货号:M385400规格:100mg / 1g 咪唑斯汀|Mizolastine|108612-45-9 咪唑斯汀原料 吲哚那非
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英文别名:
2-((1-(1-(4-Fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidin-4-yl)(methyl)amino)pyrimidin-4(1H)-one 4(1h)-pyrimidinone,2-((1-(1-((4-fluorophenyl)methyl)-1h-benzimidazol-2-yl)-4-p iperidinyl)methylamino)- 2-[[1-[1-[(4-fluorophenyl)methyl]benzoimidazol-2-yl]-4-piperidyl]-methyl-amino]-3h-pyrimidin-4-one 2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(1H)-pyrimidinone Mizolastine HCl Mizolastine; Mizolastine
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本文地址:http://www.qfopz.com.cn/cas/108612459/
文章摘要:108612,自打吞吐大帐,装甲兵国务院令语源。

国际标准相关数据

精确分子量 : 432.20700

LogP : 3.47720

PSA : 70.05000

物化性质
安全术语

海关编码 : 2933990090

化合物详情

物理化学性质

密度:1.34g/cm3折射率:1.682

概述

唑司汀是一种抗组胺药,又称为咪唑斯汀,不仅有较强的抗组胺作用,而且具有抑制其他炎症递质的作用,如抑制白三烯的产生、减轻水肿等。因而从理论上讲,咪唑斯汀既具有抗组胺、抗过敏作用,又有抗炎症活性作用,为急性荨麻疹的治疗优选药,起效明显快于其他抗组胺药,用药1~3小时后风团数量减少,瘙痒程度减轻,并且维持时间长,可达24小时。
目前临床上主要用于治疗成人或12岁以上的儿童所患的荨麻疹等皮肤过敏症状、季节性过敏性鼻炎(花粉症)及常年性过敏性鼻炎。

咪唑斯汀产品用途

【荨麻疹治疗药】咪唑司汀是一种抗组胺药,又称为咪唑斯汀,不仅有较强的抗组胺作用,而且具有抑制其他炎症递质的作用,如抑制白三烯的产生、减轻水肿等。因而从理论上讲,咪唑斯汀既具有抗组胺、抗过敏作用,又有抗炎症活性作用,为急性荨麻疹的治疗优选药,起效明显快于其他抗组胺药,用药1~3小时后风团数量减少,瘙痒程度减轻,并且维持时间长,可达24小时。目前临床上主要用于治疗成人或12岁以上的儿童所患的荨麻疹等皮肤过敏症状、季节性过敏性鼻炎(花粉症)及常年性过敏性鼻炎。
1.抗过敏。   
2.第二代非镇静性抗组胺药,长效的组胺H1受体拮抗剂。   
3.适用于急性和慢性,季节性和常年性过敏性鼻炎、荨麻疹及其他皮肤过敏。     
4.咪唑斯汀是特异性、选择性的外周组胺H1受体拮抗剂,具有抗组胺和抗变态反应活性。
 
 

应用领域





咪唑斯汀制备方法

 4-哌啶基氨基甲酸乙酯盐酸盐溶于甲醇,用5.3mol/L甲醇钠中和,过滤,滤液浓缩至干。剩余物和2-氯-1-[(4-氟苯基)甲基]-1H-苯并咪唑在140℃共热5h。加入二氯甲烷,用2mol/L氢氧化钠碱化,有机层用水洗,干燥,过滤,浓缩。油状物硅胶柱层析,得[l-[1-[(4-氟苯基)甲基]-1H-苯并咪唑-2-基]-4-哌啶基]氨基甲酸乙酯。该化合物溶于二甲基甲酰胺,在冰浴冷却下滴加含50%氢化钠的二甲基甲酰胺溶液。在室温搅拌2h,再用冰浴冷却,加入碘甲烷的二甲基甲酰胺溶液。在20℃搅拌1h后,倾入水、已烷和异丙醚的混合液中,搅拌至结晶产生。过滤收集,干燥,得[1-[l-[(4-氟苯基)甲基]-lH-苯并咪唑-2-基]-4-哌啶基]-N-甲基氨基甲酸乙酯。该化合物溶于乙酸和48%氢溴酸中,回流1.5h。浓缩至干,剩余物溶于水,用2mol/L氢氧化钠碱化,加入乙醚,搅拌至出现结晶,过滤得1-[1-[(4-氟苯基)甲基]-1H-苯并咪唑-2-基]-N-甲基-4-哌啶氨单水合物。该化合物和甲基硫脲在170℃共热10h。冷却,硅胶柱层析,得到的固体再用乙醇重结晶,得产物 

上下游产品信息




化学品安全说明书(MSDS)



储运特性





MSDS

MSDS :   Material Safety Data Sheet


Section 1. Identi?cation of the substance
    Product Name:      Mizolastine    
    Synonyms:

Section 2. Hazards identi?cation
    Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
    Ingredient name:        Mizolastine    
    CAS number:        108612-45-9    

Section 4. First aid measures
    Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing    
    contaminated clothing and shoes. If irritation persists, seek medical attention.
    Eye contact:        Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate    
    ?ushing of the eyes by separating the eyelids with ?ngers. If irritation persists, seek medical
    attention.
    Inhalation:        Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.    
    Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.    

Section 5. Fire ?ghting measures
    In the event of a ?re involving this material, alone or in combination with other materials, use dry
    powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
    should be worn.

Section 6. Accidental release measures
    Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
    standards.
    Respiratory precaution:        Wear approved mask/respirator    
    Hand precaution:        Wear suitable gloves/gauntlets    
    Skin protection:        Wear suitable protective clothing    
    Eye protection:        Wear suitable eye protection    
    Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
    for disposal. See section 12.
    Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
    Handling:        This product should be handled only by, or under the close supervision of, those properly quali?ed    
    in the handling and use of potentially hazardous chemicals, who should take into account the ?re,
    health and chemical hazard data given on this sheet.
    Store in closed vessels.
    Storage:

Section 8. Exposure Controls / Personal protection
    Engineering Controls: Use only in a chemical fume hood.
    Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
    General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
    Appearance:        Not speci?ed    
    Boiling point:        No data    
    No data
    Melting point:
    Flash point:        No data    
    Density:        No data    
    Molecular formula:        C24H25FN6O    
    Molecular weight:        432.5    

Section 10. Stability and reactivity
    Conditions to avoid: Heat, ?ames and sparks.
    Materials to avoid: Oxidizing agents.
    Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen ?uoride.

Section 11. Toxicological information
    No data.

Section 12. Ecological information
    No data.

Section 13. Disposal consideration
    Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
    disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
    Non-harzardous for air and ground transportation.

Section 15. Regulatory information
    No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
    302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
    Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

物化特性

治疗慢性过敏性鼻炎

危险品标识

风险术语标识

安全术语

扩展阅读

咪唑斯汀缓释片 咪唑斯汀缓释片,适应症为本品是长效的组胺H1受体拮抗剂,适用于成人或12岁以上的儿童所患的荨麻疹等皮肤过敏症状、季节性过敏性鼻炎(花粉症)及常年性过敏性鼻炎。

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