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6-巯基嘌呤 | 50-44-2

6-巯基嘌呤结构式图片|50-44-2结构式图片 六合彩开什么
中文名称: 6-巯基嘌呤
英文名称: 1H-Purine-6(9H)-thione
CAS No.: 50-44-2 | 分子式: C5H4N4S | 分子量: 152.17706
如需查看该化合物的详细结构式,mol文件,smile, InChi 请点击:6-巯基嘌呤结构式
MSDS:6-巯基嘌呤msds
基本信息

本文地址:http://www.qfopz.com.cn/cas/50442/
文章摘要:50,银行帐户惊世乘警,不来往飞跃重估。

中文别名:6-巯基嘌呤;埃博霉素A;巯嘌呤;6-嘌呤硫醇-水合物;;乐疾宁;6-MP;巯嘌呤;Mercaptopurine;6-MP;Mercaptopurine (6-MP);6-巯基嘌呤原料;6-巯基嘌呤50-44-2;6-巯基嘌呤|6-Mercaptopurine|50-44-2;6-巯基嘌呤|50-44-2;6-巯基嘌呤 Purity≥98%;6-巯基嘌呤 (6-MP);6MP;6-MERCAPTOPURINE 98%;6-Mercaptopurine;1H-Purine-6(9H)-thione;1,9-Dihydropurine-6-thioneDISCONTINUED, see M225450; Mercaptopurine (6-MP)
英文别名:1H-Purine-6(9H)-thione;1,9-Dihydropurine-6-thione DISCONTINUED,see M225450;6-Mercaptopurine;1H-Purine-6(9H)-thione;;purine-6-thiol;6-Mercaptopurine

国际标准相关数据

EINECS : 200-037-4

PSA : 89.45000

LogP : 1.01550

精确分子量 : 152.01600

物化性质
生产方法和用途

用途 :

抗肿瘤药。治疗急、慢性白血病、绒毛膜上皮癌和恶性葡萄胎,对恶性淋巴病和多发性骨髓瘤也有疗效。不良反应主要有恶心、呕吐、食欲降低,有时有腹泻、口腔炎和口腔溃疡。用药期间应严格检查血象,并应进行肝功能检查。肝、肾功能不良者应减量慎用。与别嘌醇合用时,应将别嘌醇减量至原剂量的25%-50%。
用于生化研究和抗肿瘤药物。
该品为次黄嘌呤类干扰核合成的药物,又称抗代谢药物。阻止核酸的合成,制止癌细胞分裂繁殖,甚至因DNA合成受阻但蛋白质合成并不停止,因而发生不平衡生长,使癌细胞死亡。巯嘌呤属于周期特异性药物,主要作用于S期,对G1期也有延缓作用;对体液免疫和细胞免疫也有抑制作用。主要用于白血病。本品也是一种生化试剂。小鼠腹腔注射LD50为157mg/kg。

方法 :

以次黄嘌呤和五硫化二磷为原料制得。
2-巯基-4-氨基-6-羟基嘧啶的制备投料质量比为氰乙酸乙酯:硫脲:乙醇钠=1:0.75:3.75。无水乙醇和乙醇钠在干燥的反应器中搅拌加热至76℃,加入硫脲,回流下滴加氰乙酸乙酯,加完后回流4h,冷却至30℃。过滤,滤饼加3.5倍水溶解并用活性炭脱色,过滤,滤液加热至90℃,滴加40%乙酸至pH4-5,冷却过滤得产品。氰乙酸乙酯[乙醇钠,硫脲,无水乙醇]→[76℃,4h;90℃,pH4-5]2-巯基-4-氨基-6-羟基嘧啶2-巯基-4,5-二氨基-6-羟基嘧啶的制备投料质量比为2-巯基-4-氨基-6-羟基嘧啶:盐酸(体积):硝酸:亚硝酸钠:保险粉=1:0.31:0.47:0.48:2.5。将2-巯基-6-氨基-6-羟基嘧啶加水溶解,加入盐酸和硝酸,15℃滴加亚硝酸钠,加完后在pH3-4条件下反应2h,抽滤,滤饼水洗至中性,加入水中,冷至20℃以下加保险粉,25℃以下反应0.5h,35℃反应2h,抽滤得产品。2-硫基-4-氨基-6-羟基嘧啶[亚硝酸钠,盐酸,硝酸]→[2h,pH3-4]2-巯基-4-氨基-5-亚硝基-6-羟基嘧啶[连二亚硫酸钠]→[<25℃,0.5h;35℃,2h]2-巯基-4,5-二氨基-6-羟基嘧啶4,5-二氨基-6-羟基嘧啶的制备投料质量比为2-巯基4,5-二氨基-6-羟基嘧啶:碳酸钠:活性镍:冰醋酸(体积)=10.751.51。将2-巯基-4,5-二氨基-6-羟基嘧啶和碳酸钠及适量水加热搅拌溶解,加入活性镍90-98℃回流4h。过滤,冰醋酸调滤液pH至7.5,减压浓缩后冷却抽滤得产品。2-巯基-4,5-二氨基-6-羟基嘧啶[碳酸钠,镍]→[90-98℃,4h]4,5-二氨基-6-羟基嘧啶6-巯基嘌呤的制备投料比为4,5-二氨基-6-羟基嘧啶(m):甲酸(V):吡啶(V):五硫化二磷(m)=1:12:13:2.7。4,5-二氨基-6-羟基嘧啶和甲酸搅拌加热溶解后回流4h,减压回收甲酸,加6mol/L氢氧化钠溶液溶解,脱色过滤,滤液冷至20℃后,冰醋酸调pH6,放置过夜,过滤,将滤饼和吡啶及五硫化二磷投入反应器中加热溶解,118℃反应4h,减压回收吡啶,冷却,加水重结晶得粗品,粗晶用水重结晶得精品。4,5-二氨基-6-羟基嘧啶[甲酸,4h]→[五硫化二磷,118℃,4h]6-巯基嘌呤。
由4,5-二氨基-6-羟基嘧啶(见1160)与甲酸环合6-羟基嘌呤(C5H4N4O),再与五硫化二磷经置换反应制得巯嘌呤。将4,5-二氨基-6-羟基嘧啶、甲酸加入反应锅中,搅拌加热溶解,升温回流4h,减压回收甲酸至尽。加入氢氧化钠溶液溶解,加活性炭脱色,过滤。滤液冷却并用冰醋酸调节pH至6,放置后过滤出结晶,即6-羟基嘌呤。将6-羟基嘌噙和五硫化二磷加入吡啶中搅拌溶解,在118℃反应4h,即生成巯嘌呤,经后处理精制而得成品,收率近60%。

安全术语

包装类别 : III

危险等级 : 6.1(b)

安全术语 : 6.1(b)

海关编码 : 2933599090

包装等级 : III

危险品运输编号 : 3249

MSDS

MSDS :   Material Safety Data Sheet


Section 1. Identi?cation of the substance
    Product Name:      6-Mercaptopurine    
    Synonyms:        1,9-Dihydro-6h-purine-6-thione    

Section 2. Hazards identi?cation
    Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
    Ingredient name:        6-Mercaptopurine    
    CAS number:        50-44-2    

Section 4. First aid measures
    Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing    
    contaminated clothing and shoes. If irritation persists, seek medical attention.
    Eye contact:        Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate    
    ?ushing of the eyes by separating the eyelids with ?ngers. If irritation persists, seek medical
    attention.
    Inhalation:        Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.    
    Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.    

Section 5. Fire ?ghting measures
    In the event of a ?re involving this material, alone or in combination with other materials, use dry
    powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
    should be worn.

Section 6. Accidental release measures
    Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
    standards.
    Respiratory precaution:        Wear approved mask/respirator    
    Hand precaution:        Wear suitable gloves/gauntlets    
    Skin protection:        Wear suitable protective clothing    
    Eye protection:        Wear suitable eye protection    
    Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
    for disposal. See section 12.
    Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
    Handling:        This product should be handled only by, or under the close supervision of, those properly quali?ed    
    in the handling and use of potentially hazardous chemicals, who should take into account the ?re,
    health and chemical hazard data given on this sheet.
    Store in closed vessels.
    Storage:

Section 8. Exposure Controls / Personal protection
    Engineering Controls: Use only in a chemical fume hood.
    Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
    General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
    Appearance:        Not speci?ed    
    Boiling point:        No data    
    No data
    Melting point:
    Flash point:        No data    
    Density:        No data    
    Molecular formula:        C5H4N4S    
    Molecular weight:        152.2    

Section 10. Stability and reactivity
    Conditions to avoid: Heat, ?ames and sparks.
    Materials to avoid: Oxidizing agents.
    Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

Section 11. Toxicological information
    No data.

Section 12. Ecological information
    No data.

Section 13. Disposal consideration
    Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
    disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
    Non-harzardous for air and ground transportation.

Section 15. Regulatory information
    No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
    302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
    Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

产品用途

用作抗肿瘤药

化合物 50-44-2 合成路线 共 5 条合成路线
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